Cellular and Molecular Biology

Many of the fundamental actors in cells—proteins, lipids, and metabolites—are still mostly invisible to us, especially when considering their extensive multiplexity, diversity, cell-to-cell heterogeneity, and temporal variation. Without scalable, cost-effective technologies to capture these molecular details, our comprehensive analysis of complex biological systems remains limited.

We are currently limited in our ability to image molecules in their native contexts—for example, within live 3D tissues. Achieving scalable, high-resolution imaging of biomolecules in situ would de-risk many areas of biomedical science by enabling integrative, comprehensive molecular mapping within intact specimens.

Cellular state is a multifaceted and complex phenomenon, involving multiple overlapping omics layers that vary in time and space. Capturing and representing this multimodal complexity is essential for predictive modeling of cell behavior and for advancing our understanding of cellular function.