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Biophysics

Lack of Structure Prediction for Highly Dynamic Proteins

Current structure prediction tools like AlphaFold excel for stable proteins but struggle with highly dynamic proteins whose structures fluctuate continuously, leaving a gap in our understanding of intrinsically disordered proteins and protein allostery.

Foundational Capabilities (2)

NMR Mapping and Modeling of Intrinsically Disordered Proteins

Utilize nuclear magnetic resonance (NMR) techniques to capture the dynamic ensembles of intrinsically disordered proteins, enabling accurate modeling of their fluctuating structures.
  • Bind: Making Proteins Druggable
    FRO

    • Protein Allostery Prediction Across the Proteome

    Develop methods to  measure and predict allosteric regulation mechanisms across the proteome, capturing dynamic conformational changes that impact protein function.
  • Mapping the energetic and allosteric landscapes of protein binding domains
    Technology Seed