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Neuroscience

Mapping the Hypothalamus and Brainstem

Systematically map how specific brain regions like the hypothalamus and brainstem (arguably the “steering subsystem” of the brain) drive innate behaviors and learning signals, and understand their role in obesity, chronic pain, fertility, inflammation, and other disorders.

Resources (7)

A comprehensive spatio-cellular map of the human hypothalamus
Research and Reviews
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Research and Reviews
Cellular atlases of the entire mouse brain
Research and Reviews
Integrated Brain Atlas for Unbiased Mapping of Nervous System Effects Following Liraglutide Treatment
Research and Reviews
Sensory input, sex and function shape hypothalamic cell type development
Research and Reviews
The molecular cytoarchitecture of the adult mouse brain
Research and Reviews
NeuroAI Safety for AI
Roadmap

R&D Gaps (1)

Current “Model Systems” for Brain Function are Not Representative of the Real Human Brain

Neuroscience
Current in vivo and in vitro models often fail to capture human brain function. Innovative model systems—including digital reconstructions, embodied simulations, and new biological models—are needed.
Neuroscience
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