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Neuroscience

Digital Replicas of the Whole Brain of a Model Organism

Construct a digital replica of a model organism’s brain (e.g., C. elegans) that accurately recapitulates neuronal activity and behavior. 

Resources (6)

A Drosophila computational brain model reveals sensorimotor processing
Research and Reviews
Large-Scale Mechanistic Models of Brain Circuits with Biophysically and Morphologically Detailed Neurons
Research and Reviews
Mapping Whole-Brain Neuronal Connectome of Larval Zebrafish
Research and Reviews
The time is ripe to reverse engineer an entire nervous system: simulating behavior from neural interactions
Research and Reviews
ZAPBench: A Benchmark for Whole-Brain Activity Prediction in Zebrafish
Research and Reviews
A Focused Research Organization to Measure Complete Neuronal Input-Output Functions
FRO Concept

R&D Gaps (1)

Current “Model Systems” for Brain Function are Not Representative of the Real Human Brain

Neuroscience
Current in vivo and in vitro models often fail to capture human brain function. Innovative model systems—including digital reconstructions, embodied simulations, and new biological models—are needed.
Neuroscience
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