3D Organoid Technology
Lab-grown 3D organ tissues have become an established additional model system to recapitulate aspects of human biology. This technology could also enable the development of functional organs for transplant.
It is also important to make tissue models that recapitulate the effects of aging, or a form of “accelerated lifetime testing”.
Resources (6)
Emulate Bio
Company
Micromatrix
Company
Human organoids: model systems for human biology and medicine
Research and Reviews
R&D Gaps (1)
Current preclinical models of human physiology, including animals and organoids, do not fully capture the complexity of human physiology, limiting the predicting power of preclinical experiments and explaining, in part, the costly failures of drug development in clinical trials. This is especially true for complex disorders including those of aging, neurological disorders, and female reproductive biology. More systematic and representative models—including ex vivo human organ systems or even whole bodies and novel animal species—are needed to improve the predictive power of biomedical research. These technologies also have applications in addressing organ shortages, improving neonatal care, and other unmet medical needs.